Zenyatta

Use the Orb of Discord to increase damage taken and deal enough damage to outweigh the healing from "Take a Breather."

By attaching an Orb of Discord to a large, slow-moving target, you can create an opening for your allies to focus their fire and take it down in one go.

Even an Orisa holding out with Fortify melts once Orb of Discord is attached, since healing can't keep up.

If you equip the Orb of Discord on a Nemesis Form—which you have to get close to and attack—your allies' firepower can take it down first.

The Orb of Discord can significantly increase the rate at which it depletes a target's maximum HP.

You can quickly melt the main body after removing the barrier using the Orb of Discord.

Pin them down one-sidedly against the back line with the lowest mobility

Be able to take out the rear guard—who has the lowest mobility—with a single shot

You can single-handedly rush in on the support with the lowest mobility and use a barrier to block their counter-orb.

You can keep knocking back the slow-moving backline

Inferno Rush closes the gap instantly on a support with no mobility of their own.

Take Aim's burst damage is effective against slow-moving rear-line units

It can reflect the Orb of Destruction and use its mobility to launch one-sided attacks.

You can keep your slow-moving rear guards within one-shot range

Joyride and Evade let Shion engage one-sidedly on a support with the lowest mobility in the game.

Use a railgun's charge shot to take out a slow-moving rear guard

Can launch surprise attacks from underground against slow-moving rear guards

You can use a booster to one-sidedly jump onto Zenyatta, who lacks mobility

Being attacked one-sidedly by the target with the lowest mobility

A rear guard lacking mobility is overwhelmed by a one-sided attack using Violent Leap